Abstract
A series of 2-alkyl-4-arylimidazoles were prepared and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to highly potent Na+ channel blockers.
MeSH terms
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Animals
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Benzimidazoles / chemical synthesis
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Benzimidazoles / pharmacology
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Binding Sites
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Brain / metabolism
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Carbolines / chemistry
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Cells, Cultured
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Electrophysiology
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Inhibitory Concentration 50
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Rats
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Sodium Channel Blockers / chemical synthesis*
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Sodium Channel Blockers / pharmacology
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Sodium Channels / metabolism*
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Structure-Activity Relationship
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Veratridine / pharmacology
Substances
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Benzimidazoles
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Carbolines
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Sodium Channel Blockers
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Sodium Channels
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Veratridine