2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. doi: 10.1016/j.bmcl.2004.04.059.

Abstract

A series of 2-alkyl-4-arylimidazoles were prepared and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to highly potent Na+ channel blockers.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Benzimidazoles / chemical synthesis
  • Benzimidazoles / pharmacology
  • Binding Sites
  • Brain / metabolism
  • Carbolines / chemistry
  • Cells, Cultured
  • Electrophysiology
  • Inhibitory Concentration 50
  • Rats
  • Sodium Channel Blockers / chemical synthesis*
  • Sodium Channel Blockers / pharmacology
  • Sodium Channels / metabolism*
  • Structure-Activity Relationship
  • Veratridine / pharmacology

Substances

  • Benzimidazoles
  • Carbolines
  • Sodium Channel Blockers
  • Sodium Channels
  • Veratridine